CELLULAR AND MOLECULAR BASIS OF PROGESTERONE-INDUCED NEUROPROTECTION

DE NICOLA A. F.; GARAY, L. I.; MEYER M; LABOMBARDA, F.; GONZALEZ DENISELLE MC

Physiological Minireviews

Sociedad Argentina de Fisiologia (SAFIS)

Lugar: Buenos Aires; Año: 2018 vol. 11 p. 57 - 75

1669-5410

Progesterone exerts several effects in the central nervous system not directly involved in reproduction or sex behavior. Non-reproductive effects are better observed under pathological conditions, and include stimulation of myelin formation, neurogenesis and neurosteroidogenesis, preserved mitochondrial function, neuroprotection, anti-inflammatory effects, decreased glutamate excitotoxicity, and regulation of mood, memory and cognition. Inaddition, the progesterone reduced derivative allopregnanolone shows anxiolytic, sedative and anesthetic properties after binding to GABAa receptors. In the present report we provide examples of [1] progesterone effects on the local synthesis of steroids (?neurosteroids?) in a demyelination model, [2] the requirement of the classical progesterone receptor for the antiinflammatory effects in mice with spinal cord injury, and [3] the protective role of progesterone and allopregnanolone in a mouse model of neurodegeneration. In conclusion, the beneficial effects observed in different experimental paradigms support the versatile properties of progesterone in animal models of central nervous system disorders.