Improving the Stability and the Pharmaceutical Properties of Norfloxacin Form C Through Binary Complexes with beta-cyclodextrin

CLAUDIA GARNERO; ANA K. CHATTAH; CAROLINA ALOISIO; LUIS FABIETTI; MARCELA LONGHI

AAPS PHARMSCITECH

SPRINGER

Lugar: Berlin; Año: 2018

1530-9932

Norfloxacin, an antibiotic existing that exist in different solid forms, has very unfavorable properties in terms of solubility and stability. Binary complexes of Norfloxacin, in the solid form C, and beta-cyclodextrin were procured by the kneading method and physical mixture. Their effect on the solubility, the dissolution rate, and the chemical and physical stability of the Norfloxacin wereas evaluated. To perform stability studies, the solid samples were stored under accelerated storage conditions, for a period of 6 months. Physical stability was monitored through powder X-ray diffraction, high resolution 13C solid-state nuclear magnetic resonance and scanning electron microscopy. The results showed evidence that the kneaded complex increased and modulated the dissolution rate of Norfloxacin C. Furthermore, it was demonstrated that the photochemical stability was increased in the complex, without affecting its physical stability. The results points to the conclusion that the new kneading complex of Norfloxacin constitutes an alternative tool to formulate a potential oral drug delivery system with improve oral bioavailability.