BECAS
BARRI Ivan Alejandro
artículos
Título:
Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
Autor/es:
SASIAMBARRENA, LEANDRO D.; BARRI, IVAN A.; FRAGA, GUIDO G.; BRAVO, RODOLFO D.; PONZINIBBIO, AGUSTÍN
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2019 vol. 60 p. 264 - 267
ISSN:
0040-4039
Resumen:
A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol?water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research.
