INVESTIGADORES
RENNA Nicolas Federico
artículos
Título:
Argentine garlic cultivars characterization by their health benefits.
Autor/es:
VAZQUEZ M; RENNA NF; CACCIAMANI V; GONZALEZ S; LAMA C; GALMARINI C; MIATELLO RM
Revista:
ACTA HORTICULTURAE
Editorial:
International Society for Horticultural Science
Referencias:
Lugar: Leuven. Nederland; Año: 2008
ISSN:
0567-7572
Resumen:
Dietary factors play a key role in the development of several human diseases, including
metabolic syndrome and cardiovascular disease. Over the centuries, garlic (Allium
sativum) has been considered as a functional food with prophylactic and therapeutic
effects. The objective was to characterize Argentine garlic cultivars through their health
benefits on a metabolic syndrome experimental model in rats.
Administration of 10% fructose solution as drinking water was used to achieve the
pathological model (FFR). Aqueous garlic extract from Fuego INTA (F) and Morado
INTA (M) cultivars were administrated by gavage (150 mg/kg/d) to FFR and control
groups. The experimental design included 6 groups (n=8 each) treated during 8 weeks.
Variables associated to metabolic syndrome: systolic blood pressure (mmHg), basal
glycemia (mg/dL) and lipid profile (mg/dL) were examined. Oxidative stress status was
evaluated through aortic NAD(P)H oxidase activity (counts/min/mg) and plasma TBARS
concentration (umol/L). In addition, vascular remodeling was studied in kidney arteries.
Changes in FFR group attributable to the pathological model development were reverted
by garlic extract administration. The beneficial effect was slightly higher when F was
administrated.
These results imply that garlic administration could be of clinical significance in primary
prevention of metabolic syndrome, provide a new insight in the understanding of the
cardiovascular benefits of nutraceutical plants in cardiovascular diseases and suggest that
slights differences in cultivar types, associated to other characteristics, could improve the
beneficial cardiovascular effects assigned to garlic consumption.
effects. The objective was to characterize Argentine garlic cultivars through their health
benefits on a metabolic syndrome experimental model in rats.
Administration of 10% fructose solution as drinking water was used to achieve the
pathological model (FFR). Aqueous garlic extract from Fuego INTA (F) and Morado
INTA (M) cultivars were administrated by gavage (150 mg/kg/d) to FFR and control
groups. The experimental design included 6 groups (n=8 each) treated during 8 weeks.
Variables associated to metabolic syndrome: systolic blood pressure (mmHg), basal
glycemia (mg/dL) and lipid profile (mg/dL) were examined. Oxidative stress status was
evaluated through aortic NAD(P)H oxidase activity (counts/min/mg) and plasma TBARS
concentration (umol/L). In addition, vascular remodeling was studied in kidney arteries.
Changes in FFR group attributable to the pathological model development were reverted
by garlic extract administration. The beneficial effect was slightly higher when F was
administrated.
These results imply that garlic administration could be of clinical significance in primary
prevention of metabolic syndrome, provide a new insight in the understanding of the
cardiovascular benefits of nutraceutical plants in cardiovascular diseases and suggest that
slights differences in cultivar types, associated to other characteristics, could improve the
beneficial cardiovascular effects assigned to garlic consumption.
sativum) has been considered as a functional food with prophylactic and therapeutic
effects. The objective was to characterize Argentine garlic cultivars through their health
benefits on a metabolic syndrome experimental model in rats.
Administration of 10% fructose solution as drinking water was used to achieve the
pathological model (FFR). Aqueous garlic extract from Fuego INTA (F) and Morado
INTA (M) cultivars were administrated by gavage (150 mg/kg/d) to FFR and control
groups. The experimental design included 6 groups (n=8 each) treated during 8 weeks.
Variables associated to metabolic syndrome: systolic blood pressure (mmHg), basal
glycemia (mg/dL) and lipid profile (mg/dL) were examined. Oxidative stress status was
evaluated through aortic NAD(P)H oxidase activity (counts/min/mg) and plasma TBARS
concentration (umol/L). In addition, vascular remodeling was studied in kidney arteries.
Changes in FFR group attributable to the pathological model development were reverted
by garlic extract administration. The beneficial effect was slightly higher when F was
administrated.
These results imply that garlic administration could be of clinical significance in primary
prevention of metabolic syndrome, provide a new insight in the understanding of the
cardiovascular benefits of nutraceutical plants in cardiovascular diseases and suggest that
slights differences in cultivar types, associated to other characteristics, could improve the
beneficial cardiovascular effects assigned to garlic consumption.
effects. The objective was to characterize Argentine garlic cultivars through their health
benefits on a metabolic syndrome experimental model in rats.
Administration of 10% fructose solution as drinking water was used to achieve the
pathological model (FFR). Aqueous garlic extract from Fuego INTA (F) and Morado
INTA (M) cultivars were administrated by gavage (150 mg/kg/d) to FFR and control
groups. The experimental design included 6 groups (n=8 each) treated during 8 weeks.
Variables associated to metabolic syndrome: systolic blood pressure (mmHg), basal
glycemia (mg/dL) and lipid profile (mg/dL) were examined. Oxidative stress status was
evaluated through aortic NAD(P)H oxidase activity (counts/min/mg) and plasma TBARS
concentration (umol/L). In addition, vascular remodeling was studied in kidney arteries.
Changes in FFR group attributable to the pathological model development were reverted
by garlic extract administration. The beneficial effect was slightly higher when F was
administrated.
These results imply that garlic administration could be of clinical significance in primary
prevention of metabolic syndrome, provide a new insight in the understanding of the
cardiovascular benefits of nutraceutical plants in cardiovascular diseases and suggest that
slights differences in cultivar types, associated to other characteristics, could improve the
beneficial cardiovascular effects assigned to garlic consumption.
Allium
sativum) has been considered as a functional food with prophylactic and therapeutic
effects. The objective was to characterize Argentine garlic cultivars through their health
benefits on a metabolic syndrome experimental model in rats.
Administration of 10% fructose solution as drinking water was used to achieve the
pathological model (FFR). Aqueous garlic extract from Fuego INTA (F) and Morado
INTA (M) cultivars were administrated by gavage (150 mg/kg/d) to FFR and control
groups. The experimental design included 6 groups (n=8 each) treated during 8 weeks.
Variables associated to metabolic syndrome: systolic blood pressure (mmHg), basal
glycemia (mg/dL) and lipid profile (mg/dL) were examined. Oxidative stress status was
evaluated through aortic NAD(P)H oxidase activity (counts/min/mg) and plasma TBARS
concentration (umol/L). In addition, vascular remodeling was studied in kidney arteries.
Changes in FFR group attributable to the pathological model development were reverted
by garlic extract administration. The beneficial effect was slightly higher when F was
administrated.
These results imply that garlic administration could be of clinical significance in primary
prevention of metabolic syndrome, provide a new insight in the understanding of the
cardiovascular benefits of nutraceutical plants in cardiovascular diseases and suggest that
slights differences in cultivar types, associated to other characteristics, could improve the
beneficial cardiovascular effects assigned to garlic consumption.
effects. The objective was to characterize Argentine garlic cultivars through their health
benefits on a metabolic syndrome experimental model in rats.
Administration of 10% fructose solution as drinking water was used to achieve the
pathological model (FFR). Aqueous garlic extract from Fuego INTA (F) and Morado
INTA (M) cultivars were administrated by gavage (150 mg/kg/d) to FFR and control
groups. The experimental design included 6 groups (n=8 each) treated during 8 weeks.
Variables associated to metabolic syndrome: systolic blood pressure (mmHg), basal
glycemia (mg/dL) and lipid profile (mg/dL) were examined. Oxidative stress status was
evaluated through aortic NAD(P)H oxidase activity (counts/min/mg) and plasma TBARS
concentration (umol/L). In addition, vascular remodeling was studied in kidney arteries.
Changes in FFR group attributable to the pathological model development were reverted
by garlic extract administration. The beneficial effect was slightly higher when F was
administrated.
These results imply that garlic administration could be of clinical significance in primary
prevention of metabolic syndrome, provide a new insight in the understanding of the
cardiovascular benefits of nutraceutical plants in cardiovascular diseases and suggest that
slights differences in cultivar types, associated to other characteristics, could improve the
beneficial cardiovascular effects assigned to garlic consumption.
) has been considered as a functional food with prophylactic and therapeutic
effects. The objective was to characterize Argentine garlic cultivars through their health
benefits on a metabolic syndrome experimental model in rats.
Administration of 10% fructose solution as drinking water was used to achieve the
pathological model (FFR). Aqueous garlic extract from Fuego INTA (F) and Morado
INTA (M) cultivars were administrated by gavage (150 mg/kg/d) to FFR and control
groups. The experimental design included 6 groups (n=8 each) treated during 8 weeks.
Variables associated to metabolic syndrome: systolic blood pressure (mmHg), basal
glycemia (mg/dL) and lipid profile (mg/dL) were examined. Oxidative stress status was
evaluated through aortic NAD(P)H oxidase activity (counts/min/mg) and plasma TBARS
concentration (umol/L). In addition, vascular remodeling was studied in kidney arteries.
Changes in FFR group attributable to the pathological model development were reverted
by garlic extract administration. The beneficial effect was slightly higher when F was
administrated.
These results imply that garlic administration could be of clinical significance in primary
prevention of metabolic syndrome, provide a new insight in the understanding of the
cardiovascular benefits of nutraceutical plants in cardiovascular diseases and suggest that
slights differences in cultivar types, associated to other characteristics, could improve the
beneficial cardiovascular effects assigned to garlic consumption.