INVESTIGADORES
CAPELLA Matias
artículos
Título:
Neutral epigenetic inheritance: being prepared for future generations
Autor/es:
CAPELLA, MATÍAS; BRAUN, SIGURD
Revista:
Nature Structural and Molecular Biology
Editorial:
Nature Publishing Group
Referencias:
Año: 2019 vol. 26 p. 391 - 392
ISSN:
1545-9993
Resumen:
Epigenetic memory of silent chromatin often requires robust feedback loops between factors processing small non-coding RNAs and enzymes involved in heterochromatin assembly. A study published in Molecular Cell now demonstrates that these feedback loops can persist in a phenotypically neutral state even when gene expression is reactivated, and that they maintain the potential to reinstall heterochromatin in later generations when conditions change.