Rat Brain Damage due to Iron and Copper Toxicity

MUSACCO SEBIO, R; SAPORITO MAGRIÑÁ, C.; FERRAROTTI, N.; ACOSTA, JM; BOVERIS, A; REPETTO, M

Austin J Neurol Disord Epilepsy.

Austin Publishing Group

Año: 2017 vol. 4

2472-3711

Brain damage is associated to oxidative stress in iron (Fe) and copper (Cu)overloads in rats, in a dose- and time-dependent accumulation of the metals inthe organ. The generation of singlet oxygen in brain measured in vivo by in situchemiluminescence indicates that Fe and Cu overloads increased phospholipidand protein oxidation, and decreased non enzymetic endogenous antioxidantscontent in the organ, mainly glutathione (GSH). These results fit with a Fenton/Haber-Weiss type reaction between iron, copper and endogenously producedsuperoxide anion (O2?-) and hydrogen peroxide (H2O2) to yield hydroxyl radical(OH?), as well as reactions involving thiol groups of GSH and proteins.