Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview

MUSACCO SEBIO, ROSARIO; SAPORITO MAGRIÑÁ, CHRISTIAN; ACOSTA JUAN MANUEL; BOVERIS ALBERTO; REPETTO, MARISA

Liver Research Open Jpurnal

Opnventio Publishers

Año: 2017 vol. 2 p. 9 - 13

2379-4038

Iron (Fe) and copper (Cu) overloads in rats showed a dose and time dependent metal accumulation in liver with its associated toxicity. The increased contents of the transition metals markedly enhanced the endogenous free-radical mediated processes of phospholipid peroxidation. In vivo liver chemiluminescence showed an increased production of 1O2, and a consumption of reduced glutathione (GSH), the main intracellular antioxidant. Results fit with a Haber-Weiss type molecular mechanism in which Fe or Cu and endogenously produced O2- and H2O2, yield HO? that initiates free-radical mediated phospholipid peroxidation and protein oxidation.