Especies reactivas del oxigeno y estres oxidativo asociadas a la infeccion por HIV

REPETTO, MARISA; LLESUY, SUSANA

Antioxidantes y Calidad de vida

Francisco Baggiani

Lugar: Buenos Aires; Año: 1999 vol. 6 p. 8 - 19

In HIV infection, the respiratory burst mediated by phagocytes is decreased by a direct damage and depletion of these cells and by the antagonistic effect of peptides released from the virus. The presence of an oxidative stress has been detected in HIV infection as shown by increased levels of malondialdheyde, lipoperoxides and chemiluminescence assay. The oxidative stress participates in the physiopatology of HIV disease in the following forms: a) virus replication, b) immune response, C) apoptosis, d) loss of weight, e) changes in glutathione pool and other antioxidant defenses. It was observed in vitro that N-acetylcysteine and glutathione, reduce apoptosis of T-lymphocytes as well as viral replication. The nuclear transcription factor of NFkB regulates the expression of numerous cytoquines, adhesion molecules, and inducible enzymes. The redox status of the cell plays an important role upon the NFkB activity. At different concentration, the free radicals may play a favorable or unfavorable role in HIV evolution.