A Preliminary Comparison of P-Tool Consistency

MURILLO JAVIER; SPETALE FLAVIO EZEQUIEL; TAPIA, ELIZABETH; KRSTICEVIC FLAVIA; OLIVE CAILLOUX; GUILLAUME SERGE; GUSTAVO VAZQUEZ; TAMARA FERNANDEZ; SÉBASTIEN DESTERCKE; PONCE, SERGIO; BULACIO, PILAR

IFMBE PROCEEDINGS

Springer, Cham

Lugar: Cham; Año: 2020 vol. 75 p. 731 - 735

1680-0737

Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the hetero-geneity of their output make their selection and comparison difficult.To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.