Baculovirus treatment fully protects mice against a lethal challenge of foot-and-mouth disease virus. Antiviral Research (2010) 87:276-279.

PAULA MOLINARI; SOLEDAD GARCÍA NUÑEZ; MARÍA J. GRAVISACO; ELISA CARRILLO; ANALÍA BERINSTEIN; OSCAR TABOGA

ANTIVIRAL RESEARCH

ELSEVIER SCIENCE BV

Año: 2010 vol. 87 p. 276 - 279

0166-3542

Foot-and-mouth disease virus (FMDV) causes a highly contagious and economically devastating diseasethat affects cattle, swine, goat and sheep among others. FMDV is able to overcome the initial host innateimmune response by inhibiting the induction of antiviral molecules at both the transcriptional and thetranslational levels. It has been demonstrated that FMDV A/Arg/2001 causes the death of adult C57Bl/6mice within 72 h.Weevaluated the capacity of Autographa californica nuclear polyhedrosis virus (AcNPV),an insect virus with potent innate immunostimulating effects, to promote early protection against FMDVA/Arg/2001 challenge in C57Bl/6 mice. Groups of 8–9 weeks old female mice were injected intravenouslywith AcNPV and challenged with a lethal dose ofFMDVat different times post-administration. Our resultsshowed that pretreatment of mice with a single injection of AcNPV 3 h or 3 days before FMDV challengeresulted in complete abrogation of mortality and complete or partial suppression of viremia, respectively.Furthermore, no signs of disease were observed. AcNPV could be a valuable tool to improve the designof a novel vaccine that protects as an adjuvant at early times post-vaccination