Water-soluble nitroxyl porphyrin complexes Fe II TPPSHNO and Fe II TPPSNO − obtained from isolated Fe II TPPSNO •

MAZZEO, AGOSTINA ; PELLEGRINO, JUAN; DOCTOROVICH, FABIO

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

AMER CHEMICAL SOC

Año: 2019 vol. 141 p. 18521 - 18530

0002-7863

The first biomimetic water soluble FeII-porphyrin nitroxyl complexes were obtained and characterized by UV-Vis in protonated and deprotonated forms by reduction of previously isolated and characterized FeIITPPSNO?. The pKa involved in the FeII-HNO ⇄ FeII-NO− + H+ equilibrium was estimated to be around 9.7. The FeIITPPSHNO complex spontaneously reoxidizes to the nitrosyl form following a first order kinetic decay with a measured kinetic constant of k = 0.017 s-1. Experiments show that the HNO adduct undergoes unimolecular homolytic cleavage of the H-NO bond. DFT calculations suggest a phlorin radical intermediate for this reaction. The deprotonated NO− complex resulted more stable, with a half-life of about 10 minutes.