A New Approach for Nonlinear Multivariable Fed-batch Bioprocess Trajectory Tracking Control

M. CECILIA FERNANDEZ; SANTIAGO RÓMOLI; M. NADIA PANTANO; D. PATIÑO; OSCAR A. ORTIZ; GUSTAVO J. E. SCAGLIA

Automatic Control and Computer Sciences

Springer

Año: 2018 vol. 52 p. 13 - 24

0146-4116

This paper proposes a new control law based on linear algebra. This technique allows nonlinear path tracking in multivariable and complex systems. This new methodology consists in finding the control action to make the system follow predefined concentration profiles solving a system of linear equations. A demonstration of the asymptotic convergence to zero of the tracking error is included. The controller parameters are selected with a Monte Carlo algorithm so as to minimize a previously defined cost index. The control scheme is applied to a fed-batch penicillin production process. Different tests are shown to prove the controller effectiveness, such as adding parametric uncertainty, perturbations in the control action and in the initial conditions. Moreover, a comparison with other controllers from the literature is made, showing the better performance of the present approach.