Modern Approaches for the Discovery of Anti-Infectious Drugs for the Treatment of Neglected Diseases

BELLERA CL; SBARAGLINI ML; TALEVI A

Current Topics in Medicinal Chemistry

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2018

1568-0266

Neglected diseases comprise a number of infectious diseases historically endemic to low- and middle-income countries, though recently they have spread to high-income countries due to human migration. In the past, pharmaceutical companies have shown hesitant to invest in these health conditions, due to the limited return on investment. As a result, the role of the academic sector and non-for-profit organizations in the discovery of new drugs for neglected diseases has been particularly relevant.Here, we review recent applications of modern drug screening technologies in the field of neglected diseases, including high-throughput screening, in silico screening and computer-aided drug design. The suitability and perspectives of each approach is discussed depending on the context, along with the technology and translational gaps influencing them.