Self-fluorescent Antibiotic MoOx-Hydroxyapatite: A Nano- theranostic Platform for Bone Infection Therapies

PLACENTE, DAMIAN; RUSO, JUAN M.; BALDINI, MÓNICA; SIEBEN, J. M.; LAIUPPA, JUAN A.; SANTILLÁN, GRACIELA E; MESSINA, PAULA VERÓNICA VERÓNICA

Nanoscale

Royal Chemical Society

Año: 2019 vol. 11 p. 17277 - 17292

2040-3364

Nowadays, the repair of large-size bone defects represents a huge medical challenge. A line of attack is the construction of advanced biomaterials havingmultifunctional properties. In this work, we show the creation of biocompatible MoOx hydroxyapatite nanoparticles (nano-HA/MoOx) that simultaneously exhibit self-activated fluorescence and antibiotic skills. Along this text, we demonstrate that the insertion of molybdenum, an essential trace element, into the non-stoichiometric calcium deficient hydroxyapatite lattice generates intrinsic electronic point defects that exacerbate its epifluorescence blue emission and provokes new red emissions; preserving, always, its bioactivity. Furthermore, these point defects, acting as electron acceptors, stimulate thematerials? biological redox status and promote the death of pathogen microorganisms after its direct contact. A putative mechanism, by which bacteria lose electrons from their metabolic circuit that alter the function of their cytoplasmic membrane and potentially die, agrees to our results.Our findings highlight the importance of tuning the electronic communications between biomaterial interfaces and biological units, and support the use of the self-fluorescent MoOx-hydroxyapatite nanoparticles as fundamental building blocks for new real-time image platforms against bone infection.