M1-like macrophage polarization prevails in young children with classic Hodgkin Lymphoma from Argentina

JIMENEZ, O.; BARROS, M. H.; DE MATTEO, E.; GARCIA LOMBARDI, M.; PRECIADO, M. V.; NIEDOBITEK, G.; CHABAY, P.

Scientific Reports

nature publishing group

Año: 2019 vol. 9

The microenvironment in classical Hodgkin lymphoma (cHL) comprises a mixture of differenttypes of cells, which are responsible for lymphoma pathogenesis and progression. Even thoughmicroenvironment composition in adult cHL has been largely studied, only few groups studied pediatriccHL, in which both Epstein Barr virus (EBV) infection and age may display a role in their pathogenesis.Furthermore, our group described that EBV is significantly associated with cHL in Argentina inpatients under the age of 10 years old. For that reason, our aim was to describe the microenvironmentcomposition in 46 pediatric cHL patients. M1-like polarization status prevailed in the whole seriesindependently of EBV association. On the other hand, in children older than 10 years, a tolerogenicenvironment illustrated by higher FOXP3 expression was proved, accompanied by a macrophagepolarization status towards M2. In contrast, in children younger than 10 years, M1-like was prevalent,along with an increase in cytotoxic GrB+ cells. This study supports the notion that pediatric cHL exhibitsa particular tumor microenvironment composition.