EXPRESIÓN DE LOS RECEPTORES DE ÁCIDO HIALURÓNICO CD44 Y RHAMM. ACTIVACIÓN DE VÍAS DE SEÑALIZACIÓN EN LA ENFERMEDAD TROFOBLÁSTICA GESTACIONAL

MASCARÓ, M; PIBUEL, M; HAJOS, SE

Revista Farmacéutica

Academia nacional de Farmacia y Bioquímica

Lugar: Capital Federal; Año: 2016 vol. 158 p. 45 - 61

0034-9496

Gestational Trophoblastic Disease (GTD) comprises a group of trophoblast-related disorders withabnormal growth of cells inside a woman ́s uterus. GTD shows specific clinical and morphologicalcharacteristics as well as pathogenesis. Some of them are benign lesions such as complete or partialhydatiform mole while others are neoplasm like choriocarcinoma and placental-site trophoblastic tumors. Itis noteworthy that all variants of GTD differ genetically from the mother and therefore constitute an allograftin maternal tissue. Hyaluronan (HA) is the major glycosaminoglycan present in the extracellular matrix. HAhas been associated with many important functions such as proliferation, wound healing, inflammation,migration and invasion, multidrug resistance or senescence. HA exerts its functions upon interaction withseveral receptors such as CD44 or RHAMM (principal receptors in cancer). Although HA-receptor interactionhas been studied in various types of tumors its participation in neoplasm associated with gestational disordersis virtually unknown. In our laboratory we evaluated the role of hyaluronan and its receptors in the processesof proliferation, migration and differentiation, including the signaling pathways involved, which could be usedas therapeutic targets for the treatment of Gestational Trophoblastic Neoplasia.