Toward biomedical application of amino-functionalized silicon nanoparticles

NATALIA CALIENNI, MARÍA; LILLO, CRISTIAN R; GOROJOD, ROXANA M; RIVAS AIELLO, MARÍA BELÉN; RODRIGUEZ SARTORI, DAMIÁN; PRIETO, MARÍA JIMENA; ALONSO, SILVIA DEL V; KOTLER, MÓNICA L; GONZALEZ, MÓNICA C; MONTANARI, JORGE

NANOMEDICINE

FUTURE MEDICINE LTD

Lugar: Londres; Año: 2018 vol. 13 p. 1349 - 1370

1743-5889

*PRIMERA AUTORÍA COMPARTIDA ENTRE LILLO Y CALIENNI // Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Aminofunctionalized silicon NPs (NH 2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two tumor cell lines) and in vivo (zebrafih larvae and embryos). NH 2SiNP showed a moderate effect as a photosensitizer for photodynamic therapy and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect. Encapsulation of NH 2SiNP into ultradeformable liposomes improved their skin penetration after topical application, reaching the viable epidermis where neoplastic events occur. Conclusion: Subsequent derivatizations after amino-functionalization and incorporation to nanodrug delivery systems could expand the spectrum of the biomedical application of these kind of silicon NPs.