Screening of Central and South American plants extracts for antimycobacterial activity by the Alamar blue test

LEITAO S; CASTRO O; FONSECA E; LISIEUX J; TAVARES E; RODRIGO L; VIEIRA R; OLIVEIRA D; LEITAO G; MARTINO V; SÜLSEN V; LOURENCO M C

REVISTA BRASILEIRA DE FARMACOGNOSIA

Brazilian Society of Pharmacognosy

Lugar: Joao Pessoa, Brasil; Año: 2006 vol. 16 p. 6 - 11

0102-695X

Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-butanol) from ten Brazilian plants (Leguminosae, Monimiaceae and Verbenaceae), 1 from Costa Rica (Verbenaceae) and 1 from Argentina (Verbenaceae) were screened for antimycobacterium activity against Mycobacterium tuberculosis (ATCC-27294 H37Rv), by the Alamar Blue test, at a fixed concentration of 100 µg/mL. Out of the forty eight, seven were active at this concentration, corresponding to Lantana trifolia (hexane and dichloromethane extracts from leaves), Vitex cooperi (methanol:water, 1:1 extract from barks), Lippia lacunosa (hexane and dichloromethane extracts from leaves) and Lippia rotundifolia (hexane and dichloromethane extracts from leaves), all from the Verbenaceae family.