INVESTIGADORES
FAILLACE Maria paula
artículos
Título:
Evidence for local synthesis of melatonin in golden hamster retina.
Autor/es:
13. FAILLACE MP, CUTRERA R, KELLER SARMIENTO MI., ROSENSTEIN
Revista:
NEUROREPORT
Editorial:
Lippincot
Referencias:
Año: 1995 vol. 6 p. 2093 - 2095
ISSN:
0959-4965
Resumen:
Daily variations in melatonin content of retinas of pinealectomized and
sham-operated golden hamsters were studied. Melatonin content showed
significant daily variations with maximal values at night (i.e. early
in the night in pinealectomized hamsters and late at night in
sham-operated animals). Moreover, mean retinal melatonin levels
augmented significantly after pinealectomy. In vitro the augmented
melatonin levels found in retinas incubated in darkness for 8 h was
suppressed by exposure to light, indicating the ability of hamster
retina to regulate melatonin synthesis in isolated conditions. Taken
together, the in vivo and in vitro results support daily variations of
melatonin content of exclusive retinal origin.