Mean platelet volume as a prognostic factor for venous thromboembolic disease

JUAN MANUEL DÍA; BRUNO BOIETTI; FERNANDO VAZQUEZ; GABRIEL WAISMAN; DIEGO GIUNTA; LILIANA ROJAS; VERONICA PEUCHOT; MARIA LOURDES POSADAS MARTINEZ

REVISTA MéDICA DE CHILE

SOC MEDICA SANTIAGO

Año: 2019

0034-9887

Background: Mean platelet volume (MPV) is a risk factor for cardiovascular and inflammatory diseases. Aim: To evaluate the association between highMPV and 90-day mortality after an episode of venous thromboembolism (VTE).Material and Methods: Retrospective cohort of 594 patients with a median ageof 73 years (58% women) with a first episode VTE, included in an institutionalThromboembolic Disease registry between 2014 and 2015. MPV values wereobtained from the automated blood cell count measured at the moment of VTEdiagnosis. Volumes ≥ 11 fL were classified as high. All patients were followed for90 days to assess survival. Results: The main comorbidities were cancer in 221patients (37%), sepsis in 172 (29%) and coronary artery disease in 107 (18%).Median MPV was 8 fl (8-9), brain natriuretic peptide 2,000 pg/ml (1,025-3,900)and troponin 40 pg/ml (19.5-75). Overall mortality was 20% (121/594) duringthe 90 days of follow-up. Thirty three deaths occurred within 7 days and 43within the first month. The loss of patients from follow-up was 5% (28/594) at90 days. Mortality among patients with high MP was 36% (23/63). The crudemortality hazard ratio (HR) for high MPV was 2.2 (95% confidence intervals(CI) 1.4-3.5).When adjusted for sepsis, oncological disease, heart disease, kidneyfailure and surgery, the mortality HR of high MPV was 2.4 (CI95% 1.5-3.9) inthe VTE group, 2.3 (CI95% 1.5-4.4) in the deep venous thrombosis group, and2.9 (CI95% 1.6 -5.6) in the pulmonary embolism group. Conclusions: HighMPV is an independent risk factor for mortality following an episode of VTE.