INVESTIGADORES
GENARO Ana Maria
artículos
Título:
Acute and chronic stress exert opposing effects on antibody responses associated with changes in stress hormone regulation of T-lymphocyte reactivity.
Autor/es:
DAFNE MAGALÍ SILBERMAN; MIRIAM R WALD; ANA MARÍA GENARO
Revista:
JOURNAL OF NEUROIMMUNOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Netherlands; Año: 2003 vol. 144 p. 53 - 60
ISSN:
0165-5728
Resumen:
Here we show that stress exerts a differential effect on T-cell-dependent antibody production. IgG production is augmented after acute stress and impaired in a chronic situation. We found catecholamines and corticosterone levels were increased in acute situations although they were not modified after prolonged stress conditions. However, lymphocyte sensitivity to corticosterone and catecholamines was altered under stress conditions. These results point out the role of the adrenal’s hormones as mediators of the differential effects of stress on the immune response providing the basis for a functional significance of stress hormone receptors on lymphocytes.