PERSONAL DE APOYO
MANCINI VILLAGRA Ulises Maximiliano
artículos
Título:
The maspin expression in canine mammary tumors: an immunohistochemical and molecular study
Autor/es:
DEBORA A.P.C. ZUCCARI; RODRIGO CASTRO; ARIELI F. GAVIOLI; ULISES M. MANCINI; ELOISA H. TAJARA; CIBELLI S. FRADE; LUANA R. PIVARO; JULIANA CARMONA-RAPHE; ANA CAROLINA B. TERZIAN; CAMILA M. RUIZ; ENY M. GOLONI BERTOLLO; ÉRIKA C. PAVARINO-BERTELLI
Revista:
PESQUISA VETERINáRIA BRASILEIRA
Editorial:
REVISTA PESQUISA VETERINARIA BRASILEIRA
Referencias:
Lugar: Rio de Janeiro; Año: 2009 vol. 29 p. 167 - 173
ISSN:
0100-736X
Resumen:
The serpin maspin, a tumor suppressor in breast cancer was described as an inhibitor of cell migration and inducer of cell adhesion between the basement membrane and extracellular matrix resulting in inhibition of tumor metastasis. In contrast, overexpression of maspin is correlated with poor prognosis in other types of cancer. Little is known about expression, regulation and function of maspin in canine mammary tumors. It was demonstrated in this study, a loss of maspin expression in malignant canine mammary cells compared with a pool of normal canine mammary tissue, analyzed by quantitative real-time PCR; weak maspin expression in malignant canine mammary tumors were observed by immunohistochemistry. It was also demonstrated that a correlation with nuclear maspin expression and a good prognosis. It is suggested that maspin could be used as a prognostic marker in canine mammary neoplasia