BACTERIAL NANO CELLULLOSE AS NON-ACTIVE PHARMACEUTICAL INGREDIENT. PRODUCTION OPTIMIZATION, QUALITY CONTROL AND FORMULATION OF SOLID PHARMACEUTICAL FORMS.

EXEQUIEL ELÍAS GONZALEZ; CERUSICO, NICOLAS ABEL; MORENO MARIA JULIETA; SESTO CABRAL MARIA EUGENIA

Drug Desingn Development and Therapy

Dove Press

Año: 2019 vol. 3 p. 35 - 44

1177-8881

Materials from bio-based resources have attracted immense research interest in recentyears as a result of their very high potentials for fabricating several high-value productswith low impact on the environment. Cellulose produced by some bacteria has receivedgreat attention. Bacterial Nano Cellulose (BNC) imparts attractive combinations ofbiophysicochemical characteristics and improved mechanical properties. The aims ofthis work was to develop growth media for increase BNC production, characterizea non-active pharmaceutical ingredient (NAPI), design an efficient quality controlmethod by FTIR and SEM by compared that NAPI with commercial on es and presenta first prototype of a pharmaceutical product. LB and KB media were modified andBNC obtained had better quality respect its crystallinity and/or polymerization degreethan the BNC from commercial media. Different extraction processes were proposed,in no case microbiological material remnants has been found. Films for controlleddrugs release prototype were made and its physical properties such as water solubility,moisture content, swelling property, UV barrier capacity were evaluated. BNC filmspresent an additional advantage, having lower UV permeability than films withcellulose of vegetal origin, adding potentialities to a patch design that protects thetissue and the Active Pharmaceutical Ingredients.