INVESTIGADORES
PRECIADO Maria Victoria
artículos
Título:
EPSTEIN BARR VIRUS IN ARGENTINE PAEDIATRIC HODGKINS DISEASE
Autor/es:
PRECIADO MV; DIEZ, B.; GRINSTEIN S
Revista:
LEUKEMIA AND LYMPHOMA
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Año: 1997 vol. 24 p. 283 - 290
ISSN:
1042-8194
Resumen:
Since Hodgkins disease (HD) is an heterogeneous condition with diverse histological and
epidemiological subgroups, it seemed worthwhile to investigate the Argentine pediatric pattern.
Moreover, the presence of Epstein Barr virus (EBV) infection occurs at different ages
depending on the development status of the country. Thus, it was interesting to assess the
relation between EBV and HD in the Argentine pediatric population. The age distribution
profile of our pediatric HD patients showed a peak in early childhood which declined towards
adolescence, closely resembling EBV infection pattern. Male:female ratio of the studied population
was 3.2: 1 and the histological subtype distribution disclosed that mixed cellularity
HD (MCHD) was the most common, an epidemiological profile shared with other developing
countries. Fifty percent of assessed HD cases were associated with EBV. showing a significantly
higher prevalence in the 3-6 year-old group, indicating a non-random distribution.
EBV was also present in most of MCHD cases and in some nodular lymphocyte predominance
HD (nLPHD) but entirely absent in nodular sclerosis HD (NSHD). Both EBV subtypes,
namely EBV-1 and EBV-2, were detected in studied HD cases. EBV-HD association
in the Argentine pediatric population reveals typical epidemiological features indicating
EBV as the aetiologic agent or, alternatively as a cofactor in a considerable percentage of
such HD cases.it seemed worthwhile to investigate the Argentine pediatric pattern.
Moreover, the presence of Epstein Barr virus (EBV) infection occurs at different ages
depending on the development status of the country. Thus, it was interesting to assess the
relation between EBV and HD in the Argentine pediatric population. The age distribution
profile of our pediatric HD patients showed a peak in early childhood which declined towards
adolescence, closely resembling EBV infection pattern. Male:female ratio of the studied population
was 3.2: 1 and the histological subtype distribution disclosed that mixed cellularity
HD (MCHD) was the most common, an epidemiological profile shared with other developing
countries. Fifty percent of assessed HD cases were associated with EBV. showing a significantly
higher prevalence in the 3-6 year-old group, indicating a non-random distribution.
EBV was also present in most of MCHD cases and in some nodular lymphocyte predominance
HD (nLPHD) but entirely absent in nodular sclerosis HD (NSHD). Both EBV subtypes,
namely EBV-1 and EBV-2, were detected in studied HD cases. EBV-HD association
in the Argentine pediatric population reveals typical epidemiological features indicating
EBV as the aetiologic agent or, alternatively as a cofactor in a considerable percentage of
such HD cases.HD patients showed a peak in early childhood which declined towards
adolescence, closely resembling EBV infection pattern. Male:female ratio of the studied population
was 3.2: 1 and the histological subtype distribution disclosed that mixed cellularity
HD (MCHD) was the most common, an epidemiological profile shared with other developing
countries. Fifty percent of assessed HD cases were associated with EBV. showing a significantly
higher prevalence in the 3-6 year-old group, indicating a non-random distribution.
EBV was also present in most of MCHD cases and in some nodular lymphocyte predominance
HD (nLPHD) but entirely absent in nodular sclerosis HD (NSHD). Both EBV subtypes,
namely EBV-1 and EBV-2, were detected in studied HD cases. EBV-HD association
in the Argentine pediatric population reveals typical epidemiological features indicating
EBV as the aetiologic agent or, alternatively as a cofactor in a considerable percentage of
such HD cases.3.2: 1 and the histological subtype distribution disclosed that mixed cellularity
HD (MCHD) was the most common, an epidemiological profile shared with other developing
countries. Fifty percent of assessed HD cases were associated with EBV. showing a significantly
higher prevalence in the 3-6 year-old group, indicating a non-random distribution.
EBV was also present in most of MCHD cases and in some nodular lymphocyte predominance
HD (nLPHD) but entirely absent in nodular sclerosis HD (NSHD). Both EBV subtypes,
namely EBV-1 and EBV-2, were detected in studied HD cases. EBV-HD association
in the Argentine pediatric population reveals typical epidemiological features indicating
EBV as the aetiologic agent or, alternatively as a cofactor in a considerable percentage of
such HD cases.of assessed HD cases were associated with EBV. showing a significantly
higher prevalence in the 3-6 year-old group, indicating a non-random distribution.
EBV was also present in most of MCHD cases and in some nodular lymphocyte predominance
HD (nLPHD) but entirely absent in nodular sclerosis HD (NSHD). Both EBV subtypes,
namely EBV-1 and EBV-2, were detected in studied HD cases. EBV-HD association
in the Argentine pediatric population reveals typical epidemiological features indicating
EBV as the aetiologic agent or, alternatively as a cofactor in a considerable percentage of
such HD cases.in the 3-6 year-old group, indicating a non-random distribution.
EBV was also present in most of MCHD cases and in some nodular lymphocyte predominance
HD (nLPHD) but entirely absent in nodular sclerosis HD (NSHD). Both EBV subtypes,
namely EBV-1 and EBV-2, were detected in studied HD cases. EBV-HD association
in the Argentine pediatric population reveals typical epidemiological features indicating
EBV as the aetiologic agent or, alternatively as a cofactor in a considerable percentage of
such HD cases.HD cases. EBV-HD association
in the Argentine pediatric population reveals typical epidemiological features indicating
EBV as the aetiologic agent or, alternatively as a cofactor in a considerable percentage of
such HD cases.