Epstein Barr virus associated Hodgkin's disease in a HIV-positive child presenting with a hemophagocytic syndrome

MARIA VICTORIA PRECIADO; DE MATTEO, E.; FALLO, A.; CHABAY, P.; DRELICHMAN, G.; GRISNTEIN, S.

LEUKEMIA AND LYMPHOMA

TAYLOR & FRANCIS LTD

Año: 2001 vol. 42 p. 231 - 234

1042-8194

An 8-years-old boy was admitted with fever of unknown origin, cervical lymphadenopathy and hepatosplenomegaly and weight loss. His mother’s HIV infection was diagnosed two weeks before his hospitalization, so he was diagnosed as perinatally acquired AIDS. Serology and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry weeks before his hospitalization, so he was diagnosed as perinatally acquired AIDS. Serology and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry weeks before his hospitalization, so he was diagnosed as perinatally acquired AIDS. Serology and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry HIV infection was diagnosed two weeks before his hospitalization, so he was diagnosed as perinatally acquired AIDS. Serology and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry as perinatally acquired AIDS. Serology and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confiied on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry as Hodgkin’s disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistryEBERs in situ hybridization and LMP-1 immunohistochemistry on the lymph node biopsy established the EBV association. On the basis of a sequence of appearance of the clinical, laboratory and histological signs, HIV, EBV or HD may have triggered HS as the last fatal event in this pediatric patient. HS as the last fatal event in this pediatric patient. HS as the last fatal event in this pediatric patient. appearance of the clinical, laboratory and histological signs, HIV, EBV or HD may have triggered HS as the last fatal event in this pediatric patient. HS as the last fatal event in this pediatric patient. HS as the last fatal event in this pediatric patient. appearance of the clinical, laboratory and histological signs, HIV, EBV or HD may have triggered HS as the last fatal event in this pediatric patient. HS as the last fatal event in this pediatric patient. HS as the last fatal event in this pediatric patient. EBV association. On the basis of a sequence of appearance of the clinical, laboratory and histological signs, HIV, EBV or HD may have triggered HS as the last fatal event in this pediatric patient. HS as the last fatal event in this pediatric patient. HS as the last fatal event in this pediatric patient. HIV, EBV or HD may have triggered HS as the last fatal event in this pediatric patient.as the last fatal event in this pediatric patient.