INVESTIGADORES
SUBURO Angela Maria
artículos
Título:
Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes
Autor/es:
BACHOR, TOMÁS P.; KARBANOVÁ, JANA; BÜTTNER, EDGAR; BERMÚDEZ, VICENTE; MARQUIONI-RAMELLA, MELISA; CARMELIET, PETER; CORBEIL, DENIS; SUBURO, ANGELA M.
Revista:
NEUROBIOLOGY OF DISEASE
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 2017 vol. 108 p. 13 - 28
ISSN:
0969-9961
Resumen:
Diabetes mellitus (DM) is reaching epidemic conditions worldwide and increases the risk for cognition impairmentand dementia. Here, we postulated that progenitors in adult neurogenic niches might be particularlyvulnerable. Therefore, we evaluated the different components of the mouse subventricular zone (SVZ) duringthe first week after chemical induction of type 1 and type 2 diabetes-like (T1DM and T2DM) conditions.Surprisingly, only T2DM mice showed SVZ damage. The initial lesions were localized to ependymal cilia,which appeared disorientated and clumped together. In addition, they showed delocalization of the ciliarymembrane protein prominin-1. Impairment of neuroprogenitor proliferation, neurogenic marker abnormalitiesand ectopic migration of neuroblasts were found at a later stage. To our knowledge, our data describe for thefirst time such an early impact of T2DM on the SVZ. This is consistent with clinical data indicating that braindamage in T2DM patients differs from that in T1DM patients.