Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats, an experimental model of metabolic syndrome.

VAZQUEZ PRIETO, MA (CA); RODRIGUEZ LANZI, C; LEMBO, C; GALMARINI, CR; MIATELLO, RM

Journal of Nutrition and Metabolism

Hindawi Publishing Corporation

Lugar: New York; Año: 2011 vol. 2011 p. 475216 - 475224

2090-0724

This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1mM as control antioxidant), F+G and F+O. Aqueous G and O extract were administered orally in doses of 150 and 400 mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity and also attenuated VCAM-1 expression. These results provide new evidence showing the anti-inflammatory and antioxidant effect of these vegetables.