Effect of Red Wine on Adipocytokine Expression and Vascular Alterations in Fructose-Fed Rats

VAZQUEZ PRIETO MA; RENNA NF; DIEZ ER; CACCIAMANI V; LEMBO C; MIATELLO RM

AMERICAN JOURNAL OF HYPERTENSION

NATURE PUBLISHING GROUP

Lugar: New York; Año: 2011 vol. 24 p. 234 - 240

0895-7061

Background: Imbalance in adipocytokines secretion is related to the development of metabolic syndrome (MS). In addition, moderate consumption of red wine decreases the risk of cardiovascular disease. The aim of this study was to evaluate the effects of moderate consumption of red wine (RW) or ethanol (E) on adiponectin and resistin expression, and vascular alterations in fructose-fed rats as an experimental model of MS. Methods: Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+E (4.5 mL/kg) and F+RW (35 mL/kg of Malbec RW containing 4.5 mL/kg E). E and RW were administered during the last 4 weeks of a 10-week period. Results: RW administration to F rats was able to significantly decrease insulin resistance, mesenteric adipose tissue weight and SBP compared to F group. F+E only reduced the SBP (p >0.05) vs. F). F+RW also reduced aortic NAD(P)H-oxidase activity, NAD(P)H subunits Nox4 expression in mesenteric tissue, plasma TBARS and recovered plasma total antioxidant activity (TAA) compared to F and F+E groups (p