INVESTIGADORES
VAZQUEZ Marcela Alejandra
artículos
Título:
Effect of chronic aspirin administration on an experimental model of metabolic syndrome.
Autor/es:
RENNA NF, VAZQUEZ MA, GONZALEZ ES, LAMA MC, MIATELLO R
Revista:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Editorial:
Blackwell Publishing Asia Pty Ltd
Referencias:
Lugar: Nueva York; Año: 2009 vol. 36 p. 162 - 168
ISSN:
0305-1870
Resumen:
SUMMARY
This study examined the effect of chronic administration of aspirin on metabolic
and cardiovascular parameters, in fructose-fed rats (FFR), an experimental
model of the metabolic syndrome.
2. Chronic treatment with aspirin partially reverted the increment in systolic blood
pressure and normalized relative heart weight and vascular remodelling of renal
and carotid arteries measured as ratio of lumen diameter to medial thickness in
FFRs.
3. Additionally, aspirin administration completely reverted glucose intolerance and
decreased the oxidative status that characterize FFR model by diminishing
plasma thiobarbituric acid reactive substances (TBARS) levels and aortic
NAD(P)H-oxidase activity.
4. Prevention of oxidative stress and vascular remodelling in FFR may contribute
to the protective properties attributed to aspirin in the treatment of metabolic
syndrome.
Key words: aspirin; fructose-fed rats; metabolic syndrome; hypertension; oxidative
stress; vascular remodelling.
stress; vascular remodelling.
stress; vascular remodelling.
stress; vascular remodelling.
stress; vascular remodelling.
aspirin; fructose-fed rats; metabolic syndrome; hypertension; oxidative
stress; vascular remodelling.