INVESTIGADORES
VAZQUEZ Fernando Javier
artículos
Título:
Prevalence of prothrombin G20210A mutation in patients with atrial fibrillation: A systematic review and meta-analysis
Autor/es:
GANDARA, ESTEBAN; BARBOZA, ANDRÉS G.; VAZQUEZ, FERNANDO
Revista:
THROMBOSIS RESEARCH
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2016 vol. 147 p. 7 - 9
ISSN:
0049-3848
Resumen:
Prothrombin G20210A is a common genetic mutation associated with venous thromboembolism that has also been associated with arterial disease. Structural and functional changes in arteries, such as the carotid intima-media thickness, are important atherosclerotic risk markers that are linked to the pathogenesis of atrial fibrillation. Thrombin plays a key role in regulating vascular tone, permeability, migration and proliferation of vascular smooth muscle cells, and induction of diverse pro-inflammatory markers which lead to the progression of cardiovascular disease.
