INVESTIGADORES
PEREZ Sandra Elizabeth
artículos
Título:
Toll-like receptor expression in the nervous system of bovine alpha-herpesvirus-infected calves
Autor/es:
MARIN, M; QUINTANA, S; LEUNDA, M; ODEÓN, A; PÉREZ, S
Revista:
RESEARCH IN VETERINARY SCIENCE
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2014 p. 422 - 429
ISSN:
0034-5288
Resumen:
In this study, the expression levels of viral Toll-like receptors (TLRs) in the nervous system of bovine herpesvirus
type 5 (BoHV-5)-infected calves were investigated. A significant increase in the expression of
TLRs 3 and 7?9 was found in the anterior cerebral cortex during acute infection and viral reactivation.
In the trigeminal ganglia, only TLR9 expression was significantly affected. The magnitude of the increase
was lower in BoHV-1-infected calves, suggesting that a restricted immune response might protect
against exacerbated inflammatory responses in the brain. This work describes, for the first time, the involvement
of TLRs 3 and 7?9 in the recognition of BoHV in the bovine nervous system, indicating that
the expression of these receptors might be associated with the development of neurological disease. Modulation
of the signalling pathways mediated by TLRs might provide an effective approach to control the
neuro-immune response to BoHV-5, which may be responsible for neurological lesions.