Caged aminoacids for visible light photodelivery

MARCELO SALIERNO; CECILIA FAMELI; ROBERTO ETCHENIQUE

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

WILEY-V C H VERLAG GMBH

Año: 2008 p. 1125 - 1128

1434-1948

We present a photocleavable protecting group based on ruthenium bipyridyl complexes and suitable for amino acid photodelivery. We discuss the photochemical properties of the caged glutamate, which is a major neurotransmitter in the CNS. The molar absorptivity for the caged glutamate at 450 nm is å = 4200 M–1cm–1 and its quantum yield of photore- lease at 450 nm is ÖPD = 0.035, which is about 17 times higher than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids. acids. than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids. acids. than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids. acids. lease at 450 nm is ÖPD = 0.035, which is about 17 times higher than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids. acids. than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids. acids. than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids. acids. lease at 450 nm is ÖPD = 0.035, which is about 17 times higher than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids. acids. than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids. acids. than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alfa amino acids. acids.