Effects of sodium tungstate and vanadilo sulfate on prostanoids release from the mesenteric vascular bed of diabetic rats

LEE HJ; PEREDO H; CANTÚ SM; DONOSO AS; PUYÓ AM; CHOI MR

Clínica e Investigación en Arteriosclerosis

Elsevier

Lugar: Barcelona; Año: 2018

0214-9168

Introduction: Transition metal compounds such as tungsten and vanadium have been proposed as possible agents in the treatment of diabetes due to its insulin-mimetic effects. The mesenteric vascular bed participates in vascular resistance and constitutes a source of vasoactive compounds such as prostanoids. The aim of this study was to evaluate the effects of sodium tungstate and vanadyl sulfate on metabolic parameters and prostanoids release from the mesenteric vascular bed in an experimental model of streptozotocin-induced diabetes.  Methods: Wistar male rats were divided into six groups: control; diabetics; treated with tungstate; treated with vanadyl; diabetics treated with tungstate and diabetics treated with vanadyl. Results: In diabetic rats a significant increase in plasma levels of glucose, triglycerides and total cholesterol was observed. On the other hand, a significant reduction in the release of vasodilator prostanoids such as prostacyclin and prostaglandin E2 and vasoconstrictor thromboxane A2 was observed in the mesenteric vascular bed. Both sodium tungstate and vanadyl sulfate normalized glycemia, triglyceridemia and cholesterol in diabetic rats. On the other hand, only treatment with sodium tungstate reversed the reduction on prostanoid-vasodilators release, improving the prostacyclin/thromboxane ratio in diabetic animals, an indicator of vascular dysfunction.  Conclusion: unlike vanadyl sulphate, sodium tungstate proves to be more effective in controlling metabolic alterations and the production of vasodilator prostanoids observed in experimental diabetes induced by streptozotocin.