Superantigens and retroviral infections. Increase of mammary tumorigenicity due to recombination between exogenous and endogenous MMTV viruses

IRENE NEPOMNASCHY; VALERIA BUGGIANO; ALEJANDRA GOLDMAN; ADRIANA DEROCHE; PEDRO BEKINSCHTEIN; PAULA BERGUER; ISABEL PIAZZON

MEDICINA (BUENOS AIRES)

Año: 1997 vol. 57 p. 327 - 331

0025-7680

A number of milk-borne exogenous mouse mammary tumor viruses (MMTV) infect mice shortly after birth and, when expressed, produce superantigens. Herein we describe the biological effects of new variants of exogenous MMTV: one of them (BALB14) present in BALB/c mice and showing a low ability to induce mammary tumors, and the other (MMTV-7) being the result of recombination between the BALB14 and the Mtv-7 endogenous provirus. The recombinant virus which has the SAg-specificity of Mtv-7 was amplified in BALB/c mice this fact correlating with a high incidence of mammary tumors. The role of strong SAgs in the mechanism by which the recombinant virus increases its title in a susceptible host is discussed. The results obtained suggest that the presence of non-productive endogenous proviruses--considered as conferring a selective advantage to the mouse population by protecting it from infection with exogenous MMTV--should also be advantageous to the pathogen by increasing its variability, thus broadening the host range and allowing the expansion of highly tumorigenic variants.