INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
artículos
Título:
Delayed wave of c-Fos expression in the dorsal hippocampus involved specifically in persistence of long-term memory storage
Autor/es:
CYNTHIA KATCHE; PEDRO BEKINSCHTEIN; LEANDRO N. SLIPCZUK; ANDREA GOLDIN; IVAN IZQUIERDO; MARTÍN CAMMAROTA; JORGE H. MEDINA
Revista:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Editorial:
NATL ACAD SCIENCES
Referencias:
Año: 2009 vol. 107 p. 349 - 354
ISSN:
0027-8424
Resumen:
Memory formation is a temporally graded process during which
transcription and translation steps are required in the first hours
after acquisition. Although persistence is a key characteristic of
memory storage, its mechanisms are scarcely characterized. Here, we show
that long-lasting but not short-lived inhibitory avoidance long-term
memory is associated with a delayed expression of c-Fos in the
hippocampus. Importantly, this late wave of c-Fos is necessary for
maintenance of inhibitory avoidance long-term storage. Moreover,
inhibition of transcription in the dorsal hippocampus 24 h after
training hinders persistence but not formation of long-term storage.
These findings indicate that a delayed phase of transcription is
essential for maintenance of a hippocampus-dependent memory trace. Our
results support the hypothesis that recurrent rounds of
consolidation-like events take place late after learning in the dorsal
hippocampus to maintain memories.