INVESTIGADORES
BRIAND Laura Estefania
artículos
Título:
Relevance and Bio-Catalytic Strategies for the Kinetic Resolution of Ketoprofen towards Dexketoprofen
Autor/es:
MARIA VICTORIA TOLEDO; LAURA E. BRIAND
Revista:
CRITICAL REVIEWS IN BIOTECHNOLOGY
Editorial:
TAYLOR & FRANCIS INC
Referencias:
Lugar: Londres; Año: 2018 vol. 38 p. 778 - 800
ISSN:
0738-8551
Resumen:
This review presents the most relevant investigations concerning the biocatalytic kinetic resolution of racemic ketoprofen to dexketoprofen for the last 22 years. The advantages related to the administration of the dex-enantiomer in terms of human health, the so called ?chiral switch? in the pharmaceutical industry and the sustainability of biotransformations have been the driving forces to develop innovative technology to obtain dexketoprofen. In particular, the kinetic resolution of racemic ketoprofen through enantiomeric esterification and hydrolysis using lipases as biocatalysts are thoroughly revised and commented. In this context, the biocatalysts, acyl-acceptors (alcohols), reaction conditions, conversion, enantiomeric excess and enantiomeric ratio among others are discussed.Moreover, the investigations concerning scaling up processes in order to obtain an optically pure enantiomer of the profen are presented. Finally some guidelines about perspectives of the technology and research opportunities are given.