RELATIONSHIP BETWEEN COGNITIVE AND SLEEP-WAKE VARIABLES IN ASYMPTOMATIC OFFSPRING OF PATIENTS WITH LATE-ONSET ALZHEIMER’S DISEASE

ABULAFIA, CAROLINA; DUARTE-ABRITTA, BARBARA; VILLAREAL, MIRTA F.; LADRÓN-DE-GUEVARA, SOLEDAD; GARCIA, CELESTE; SEQUEYRA, GERALDINE; SEVLEVER, GUSTAVO; FIORENTINI, LETICIA; BÄR, KARL-JÜRGEN; GUSTAFSON, DEBORAH R.; VIGO, DANIEL E.; GUINJOAN, SALVADOR MARTIN

ALZHEIMERS & DEMENTIA

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2017 vol. 13

1552-5260

Early neuropathological changes characteristic of late-onset Alzheimer´s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer´s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler´s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.