Brain Structural and Amyloid Correlates of Recovery from Semantic Interference in Cognitively Normal Individuals with or without Family History of Late-Onset Alzheimer´s Disease

ABULAFIA, CAROLINA; LOEWENSTEIN, DAVID A; CURIEL, ROSIE; DUARTE ABRITTA, BARBARA; SANCHEZ, STELLA M; VIGO, DANIEL E; CASTRO, MARIANA N; DRUCAROFF, LUCAS J.; VAZQUEZ, SILVIA; SEVLEVER, GUSTAVO; NEMEROFF, CHARLES B; GUINJOAN, SALVADOR M; VILLAREAL, MIRTA F.

J. NEUROPSYCHIATRY CLIN. NEUROSCI.

AMER PSYCHIATRIC PUBLISHING, INC

Año: 2018

0895-0172

Objective: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer?s disease (AD). We sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset AD (O-LOAD), compared with individuals without family history of neurodegenerative disorders (CS). Method: We evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3T MRI volumetry, and PET-PiB, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Results: Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in AD in the latter. Better recovery from retroactive semantic interference was associated to less amyloid load in the left temporal lobe in O-LOAD, but not CS. Conclusions: In middle-aged, cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD, involve AD-relevant brain regions even at a relatively young age.