INVESTIGADORES
LUX Victoria Adela R.
artículos
Título:
Development of an Experimental Ovarian Tumor over a Year in the Rat
Autor/es:
CHAMSONREIG, A; BIANCHI, MS; REYROLDAN, E; SORIANELLO, E; LIBERTUN, C; LUXLANTOS, V; VICTORIA ADELA R LUX
Revista:
LIFE SCIENCES
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1999 vol. 65 p. 1275 - 1285
ISSN:
0024-3205
Resumen:
Tumor growth, possible malignant transformation or metastatic propagation and
hormonal patterns were evaluated over a year in luteomainduced by introducing an
ovary into the spleen of ovariectomized 60 day-old rats. Sham castrated animals had
a piece of muscle inserted into the spleen. Jugular blood samples were taken
monthly. Atter a year animals were cycled and decapitated. Troncal blood was
collected, autopsies were performed and luteoma were measured and fixed in 10%
buffered formalin. Serum LH, FSH, PRL, estradiol and progesterone were
measured. Serum inhibin content was determined in one month-old tumors-bearing
animals and estrous rats as controls. After one year no external changes in tumorbearing
rats were observed, nor differences in body weight or mortality rates
compared to Sham animals. Metastatic propagation was absent. Routine histological
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
a piece of muscle inserted into the spleen. Jugular blood samples were taken
monthly. Atter a year animals were cycled and decapitated. Troncal blood was
collected, autopsies were performed and luteoma were measured and fixed in 10%
buffered formalin. Serum LH, FSH, PRL, estradiol and progesterone were
measured. Serum inhibin content was determined in one month-old tumors-bearing
animals and estrous rats as controls. After one year no external changes in tumorbearing
rats were observed, nor differences in body weight or mortality rates
compared to Sham animals. Metastatic propagation was absent. Routine histological
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
a piece of muscle inserted into the spleen. Jugular blood samples were taken
monthly. Atter a year animals were cycled and decapitated. Troncal blood was
collected, autopsies were performed and luteoma were measured and fixed in 10%
buffered formalin. Serum LH, FSH, PRL, estradiol and progesterone were
measured. Serum inhibin content was determined in one month-old tumors-bearing
animals and estrous rats as controls. After one year no external changes in tumorbearing
rats were observed, nor differences in body weight or mortality rates
compared to Sham animals. Metastatic propagation was absent. Routine histological
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
a piece of muscle inserted into the spleen. Jugular blood samples were taken
monthly. Atter a year animals were cycled and decapitated. Troncal blood was
collected, autopsies were performed and luteoma were measured and fixed in 10%
buffered formalin. Serum LH, FSH, PRL, estradiol and progesterone were
measured. Serum inhibin content was determined in one month-old tumors-bearing
animals and estrous rats as controls. After one year no external changes in tumorbearing
rats were observed, nor differences in body weight or mortality rates
compared to Sham animals. Metastatic propagation was absent. Routine histological
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
Sham castrated animals had
a piece of muscle inserted into the spleen. Jugular blood samples were taken
monthly. Atter a year animals were cycled and decapitated. Troncal blood was
collected, autopsies were performed and luteoma were measured and fixed in 10%
buffered formalin. Serum LH, FSH, PRL, estradiol and progesterone were
measured. Serum inhibin content was determined in one month-old tumors-bearing
animals and estrous rats as controls. After one year no external changes in tumorbearing
rats were observed, nor differences in body weight or mortality rates
compared to Sham animals. Metastatic propagation was absent. Routine histological
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: Large
Sham animals. Metastatic propagation was absent. Routine histological
examination showed two types of tumors according to either granulosa or luteal cell
predomination, tumor type did not determine hormonal patterns. However, a clear
relationship between gonadotropin levels and tumor size was established. Low
gonadotropins: Small tumors, 18.7 % of cases and high gonadotropins: LargeSmall tumors, 18.7 % of cases and high gonadotropins: Large
tumors, 81.3 %. In Sham animals gonadotropins attained castrate levels and
remained elevated until the end of the experiment. In the Small group no increases
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
remained elevated until the end of the experiment. In the Small group no increases
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
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levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
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levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
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levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
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Corresponding author:
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remained elevated until the end of the experiment. In the Small group no increases
in gonadotropins or estradiol were detected, progesterone and PRL fluctuated. In
the Large tumor group LH increased to Sham titers until month 7, then fell to initial
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
Corresponding author:
Corresponding author:
levels, FSH augmented significantly as from month three and remained high up to
month 5. No variations in either estradiol, progesterone or PRL were observed.
Serum inhibin of one month-old tumor-bearing rats was significantly elevated,
justifying the lack of FSH increase at this time point. We conclude that these
luteoma do not suffer malignant transformation or induce metastases. They appear
in two histological types. Tumor size depends on hormonal patterns. The delay in
the initial increase and the sharp decrease observed in FSH in animals bearing Large
tumors suggest a possible role for inhibin in this regulation.
Key Words: ovarian tumor, histology, gonadotropins, steroid honnones, inbibins
Corresponding author:
Corresponding author:
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