INVESTIGADORES
MIRANDA Leandro Andres
artículos
Título:
Gonadotropin-releasing hormone (GnRH): from fish to mammalian brains.
Autor/es:
GUSTAVO SOMOZA,; MIRANDA, LEANDRO ANDRES; LEONARDO GUILGUR,; STROBL MAZZULLA, PABLO
Revista:
CELLULAR AND MOLECULAR NEUROBIOLOGY.
Editorial:
SPRINGER/PLENUM PUBLISHERS
Referencias:
Año: 2002 vol. 22 p. 589 - 609
ISSN:
0272-4340
Resumen:
1. This work deals with a family of neuropeptides, gonadotropin-releasing hormone
(GnRH), that play a key role in the development and maintenance of reproductive function
in vertebrates.
2. Until now, a total of 16 GnRH structural variants have been isolated and characterized
from vertebrate and protochordate nervous tissue. All vertebrate species already
investigated have at least two GnRH forms coexisting in the central nervous system. However,
it is now well accepted that three forms of GnRH in early and late evolved bony fishes
are present.
3. In these cases, cGnRH-II is expressed by midbrain neurons, a species-specificGnRH
is present mainly in the preoptic area and the hypothalamus, and sGnRH is localized in the
terminal nerve ganglion (TNG). In this context it is possible to think that threeGnRHforms
and three GnRH receptor (GnRH-R) subtypes are expressed in the central nervous system
of a given species.
4. Then it is possible to propose three different GnRH lineages expressed by distinct
brain areas in vertebrates: (1) the conserved cGnRH-II or mesencephalic lineage; or (2)
the hypothalamic or releasing lineage whose primary structure has diverged by point
mutations (mGnRH and its orthologous forms: hrGnRH, wfGnRH, cfGnRH, sbGnRH,
and pjGnRH); and (3) the telencephalic sGnRH form. Also differentGnRHnomenclatures
are discussed.