Gene polymorphism profiles of drug-metabolizing enzymes GSTM1, GSTT1 and GSTP1 in an Argentinean population

WEICH N; ROISMAN A; CERLIANI B; ARÁOZ HV; CHERTKOFF L; RICHARD SM; SLAVUTSKY IR; LARRIPA IB; FUNDIA AF

ANNALS OF HUMAN BIOLOGY

TAYLOR & FRANCIS LTD

Lugar: Londres; Año: 2017 vol. 44 p. 379 - 383

0301-4460

Background: Glutathione S-transferases (GSTs) are drug-metabolizing enzymes involved in biotransformation of carcinogens, drugs, xenobiotics and oxygen free radicals. Polymorphisms of GST genes contribute to inter-individual and population variability in the susceptibility to environmental risk factors, cancer predisposition and pharmacotherapy responses. However, data about GST variability in Argentina are lacking.Aim: The purpose was to determine the prevalence of GSTM1, GSTT1 and GSTP1 polymorphisms the general population from a central region of Argentina and to perform inter-population comparisons. Subjects and Methods: GSTM1 and GSTT1 gene deletions and GSTP1 c.313A>G were genotyped by PCR assays in 609 healthy and unrelated Argentineans.Results: The frequencies of variant genotypes in Argentineans were GSTM1-null (45%), GSTT1-null (17%) and GSTP1-GG (11%). GSTM1-positive genotype was significantly associated with GSTP1-AG or GSTP1-GG variants (p=0.037; p=0.034, respectively). Comparison with worldwide populations demonstrated that the GST distributions in Argentina are similar to those reported for Italy and Spain, whereas significant differences were observed regarding Asian and African populations (p