INVESTIGADORES
RISK Marcelo Raul
artículos
Título:
A new approach to assist postoperative heart failure in an animal model: juxta-aortic counterpulsation
Autor/es:
EDMUNDO I. CABRERA FISCHER; ALEJANDRA CHRISTEN; MARCELO RISK; FRANCO PESSANA; EDUARDO DE FORTEZA
Revista:
ARTIFICIAL ORGANS
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2002 vol. 26 p. 819 - 826
ISSN:
0160-564X
Resumen:
Aortic counterpulsation is a useful technique
frequently used in postcardiotomy heart failure. An acute
heart failure model in open chest sheep was chosen to
evaluate hemodynamic improvement with a counterpulsation
balloon pump in juxta-aortic position. This was
achieved with a manufactured Dacron prosthesis and a
balloon pump placed between the prosthesis and the aorta.
Juxta-aortic balloon pump counterpulsation in acute experimental
heart failure resulted in a significant improvement
of hemodynamic parameters: increase of cardiac output
(from 0.86 ± 0.04 to 1.29 ± 0.09 L/min, p < 0.05) and
cardiac index (from 0.03 ± 0.01 to 0.04 ± 0.01 L/min per kg,
p < 0.05), and decrease of systemic vascular resistance
(from 89.76 ± 6.69 to 66.56 ± 6.02 mm Hg/L per min,
p< 0.05). The extent of aortic diastolic pressure change evaluated
through the diastolic and systolic areas beneath the
aortic pressure curve (DABAC/SABAC) index before
cardiac failure induction showed a significant increase
compared with unassisted values (from 0.81 ± 0.10 to
1.12 ± 0.09, p < 0.05). Assisted values of DABAC/SABAC
index after heart failure induction also showed a significant
increase compared with unassisted values (from
0.78 ± 0.21 to 1.17 ± 0.38, p < 0.05). Treatment of experimental
acute heart failure by juxta-aortic balloon pump
counterpulsation allows an effective hemodynamic improvement
in open chest sheep.