CEMIC - CONICET 26185
CENTRO DE EDUCACION MEDICA E INVESTIGACIONES CLINICAS "NORBERTO QUIRNO"
Unidad Ejecutora - UE
artículos
Título:
Tissue alkalosis in cold-ischemia time
Autor/es:
CAMPOS, A. H. J. FRÓES MARQUES; MARTINS, V.R.; MOTA, L.; OLIVIERI, E.H.R.; AVAGNINA, A.; SUENAGA, A.P.; FRESNO, C.; SOARES, F.A.; CARRARO, D.M.; UCEDA, A.; DENNINGHOFF, V.
Revista:
Scientific Reports
Editorial:
Nature Publishing Group
Referencias:
Año: 2017 vol. 7
Resumen:
The control of pre-Analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.
