Lymph node ratio as prognosis factor for colon cancer treated by colorectal surgeons.

CARLOS A. VACCARO; VICTOR M. IM,; GUSTAVO L. ROSSI; GUILLERMO OJEA QUINTANA; MARIO L. BENATI; PEREZ DE ARENAZA D; FERNANDO A. BONADEO

DISEASES OF THE COLON AND RECTUM.

LIPPINCOTT WILLIAMS & WILKINS

Lugar: Philadelphia; Año: 2009

0012-3706

PURPOSE:This study was designed to assess the prognostic value of the lymph node ratio in patients with colon cancer treated by colorectal specialists.METHODS:Three hundred and sixty-two Stage III consecutive cases were analyzed based on quartiles: lymph node ratio 1 (>0 and 0.12 and or=0.25).RESULTS:Disease-free survival rates were: lymph node ratio 1, 75.5%; lymph node ratio 2, 74.2%; lymph node ratio 3, 73.2%; and lymph node ratio 4, 40.1%. Similar differences were observed for cancer-specific and overall survival rates. Cases with lymph node ratio >or=0.25 had higher hazard ratios than cases with lymph node ratio or=0.25 was higher than that of cases with up to three positive nodes and lymph node ratios or=0.25 was an independent prognostic factor in Stage III colon adenocarcinoma regardless of the number positive nodes. It modified outcomes predicted by the current staging system.