Association between mast cells of different phenotypes and angiogenesis in colorectal cancer.

MAURO LV; BELLIDO M; ANA MORANDI; FERNANDO BONADEO; CARLOS A. VACCARO; GUILLERMO OJEA QUINTANA; PALLOTTA MG; JOSÉ MARÍA LASTIRI; , PURICELLI LI; DE CIDRE LL

MOLECULAR MEDICINE REPORTS

SPANDIDOS PUBL LTD

Lugar: Atenas; Año: 2008

1791-2997

It is known that mast cells proliferate in solid tumours and increase tumour angiogenesis. Nevertheless, there is no consensus regarding their role in colorectal cancer (CRC). In this study, we aimed to clarify the relationship of mast cells positive for tryptase (MCts) and tryptase-chymase (MCtcs) with microvessel density (MVD) in the intratumoral zone and the invasive edge of 80 CRC patient tumours. We evaluated these parameters and associated their expression with clinicopathological parameters, including survival rate. Tumour sections from each patient were immunostained for tryptase to evaluate MCts, chymase to evaluate MCtcs, and CD34 to evaluate microvessel counts under x100 microscopy. The number of MCs of both phenotypes and the MVD counts were higher in the invasive edge than in the intratumoral zone (p