Risk of conversion to dementia in a mild behavioral impairment group compared to a psychiatric group and to a mild cognitive impairment group

TARAGANO FERNANDO. ; ALLEGRI RICARDO. ; SILVINA HEISECKE. ; MARIA MARTELLI. ; MONICA FELDMAN. ; VIVIANA SANCHEZ; VIRGINIA GARCIA. ; GRACIELA TUFRO. ; DIEGO CASTRO.; PATRICIO PEREZ LEGUIZAMON. ; VERÓNICA GUELAR.; EVA ROTUOLO. ; CECILIA ZEGARRA. ; CAROL DILLON.

Journal of Alzheimer`s disease

IOS Press

Año: 2018 vol. 62 p. 227 - 238

Background. There is insufficient available information on behavioral changes in theabsence of cognitive impairment as factors increasing the risk of conversion todementia.Objective. To observe and analyze patients with Mild Behavioral impairment (MBI), Mild Cognitive Impairment (MCI) and a psychiatry group (PG) to compare the risk of progression to dementia.Methods. From 677 initially assessed ≥60 year old patients, a series of 348 patientswas studied for a five year period until censoring or conversion to dementia: 96 withMBI, 87 with MCI and 165 with general psychiatry disorders, including 4 subgroups:Anxiety, Depression, Psychosis and Others. All patients were assessed with clinical,psychiatric, neurological, neuropsychological and neuroimaging studies. Results. From 348 patients, 126 evolved to dementia (36.2%). Conversion was significantly higher in MBI 71.5% followed by MCI-MBI overlap group (59.6%) and MCI (37.8%) group, compared to PG 13.9% (Log-rank p