INQUISAL   20936
INSTITUTO DE QUIMICA DE SAN LUIS "DR. ROBERTO ANTONIO OLSINA"
Unidad Ejecutora - UE
artículos
Título:
SOLUBILITY AND PREFERENTIAL SOLVATION OF PIROXICAM IN NEAT SOLVENTS AND BINARY SYSTEMS
Autor/es:
GT CASTRO, MA FILIPPA, CM PERALTA, MV DAVIN, MC ALMANDOZ AND EI GASULL; GT CASTRO, MA FILIPPA, CM PERALTA, MV DAVIN, MC ALMANDOZ AND EI GASULL
Revista:
Zeitschrift für Physikalische Chemie
Editorial:
OLDENBOURG VERLAG
Referencias:
Año: 2017
ISSN:
0942-9352
Resumen:
The solubilization and solvatochromic behavior of piroxicam (PRX)were analyzed using UV-vis spectroscopy in neat (protic and aprotic) andbinary solvent mixtures. The effects of solvent dipolarity/polarizability andsolvent?solute hydrogen bonding interactions on the absorption maxima wereevaluated by means of the linear solvation energy relationship concept ofKamlet and Taft. This analysis indicated that both interactions play an important role in the position of the absorption maxima in neat solvents. While, the PRX solubility depends on the solute?solvent specific interactions, polarizability and the cohesive forces of the solvent, manifested mainly by means of the Hildebrand?s solubility parameter. Preferential solvation (PS) was studied in 10 binary mixtures. A non-ideal behavior of the wavenumber curve as the function of analytical mole fraction of co-solvent was detected. Index of preferential solvation, as well as the influence of solvent parameters were calculated. The process of dissolution was analyzed in aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol. They were not spontaneous in all proportions, but when water concentration decreases in the mixtures, the process becomes more spontaneous.