INVESTIGADORES
SANCHEZ BRUNI Sergio Fabian
artículos
Título:
Albendazole nanocrystals with improved pharmacokinetic performance in mice
Autor/es:
PAREDES, A.; SANCHEZ BRUNI S.; ALLEMANDI, D.; LANUSSE,CC; PALMA S.
Revista:
Therapeutic Delivery
Editorial:
Future Science
Referencias:
Lugar: London; Año: 2018 vol. 92 p. 89 - 97
ISSN:
2041-5990
Resumen:
Aim: Albendazole (ABZ) is a broad-spectrum antiparasitic agent with poor aqueous solubility, which leadsto poor/erratic bioavailability and therapeutic failures. Here, we aimed to produce a novel formulationof ABZ nanocrystals (ABZNC) and assess its pharmacokinetic performance in mice. Results/methodology:ABZNC were prepared by high-pressure homogenization and spray-drying processes. Redispersion capacityand solid yield were measured in order to obtain an optimized product. The final particle size was415.69±7.40 nm and the solid yield was 72.32%. The pharmacokinetic parameters obtained in a micemodel for ABZNC were enhanced (p < 0.05) with respect to the control formulation. Conclusion: ABZNCwith improved pharmacokinetic behavior were produced by a simple, inexpensive and potentially scalablemethodology.First draft
