A comprehensive bioinformatic analysis of hepatitis D virus (HDV) full-length genomes

DELFINO, CECILIA MARÍA; CERRUDO, CAROLINA SUSANA; BIGLIONE, MIRNA; OUBIÑA, JOSÉ RAÚL; GHIRINGHELLI, PABLO DANIEL; MATHET, VERÓNICA LIDIA

JOURNAL OF VIRAL HEPATITIS.

WILEY-BLACKWELL PUBLISHING, INC

Año: 2018

1352-0504

AbstractIn association with hepatitis B virus (HBV), hepatitis delta virus (HDV) is a subviral agent that may promote severe acute and chronic forms of liver disease. Based on the percentage of nucleotide identity of the genome, HDV was initially classified into three genotypes. However, since 2006, the original classification has been further expanded into eight clades/genotypes. The intergenotype divergence may be as high as 35-40% over the entire RNA genome, whereas sequence heterogeneity among the isolates of a given genotype is