Antioxidant Neolignans from Cordia americana

FERNÁNDEZ, LUCÍA; CIRIGLIANO, ADRIANA; FABANI, M. PAULA; LIMA, BEATRIZ; ALBERTI, SEBASTIAN; KRAMER, FERNANDO; TAPIA, ALEJANDRO; CABRERA, GABRIELA; PALERMO, JORGE A.; SANCHEZ, MARIANELA

PLANTA MEDICA

GEORG THIEME VERLAG KG

Lugar: New York; Año: 2013

0032-0943

    Five new neolignans with a bicyclo[2.2.2]octane framework were isolated from an ethanolic extract of the bark of Cordia americana. The structures and relative configurations of the compounds were elucidated by a combination of spectroscopic methods. All the isolated compounds showed good antioxidant activities in the DPPH radical scavenging (0.5?100 µg/mL) and Ferric-reducing antioxidant power (FRAP, 1?100 µg/mL) assays. One of the compounds displayed mild fungistatic activity at 0.1 µmol/spot against Fusarium virguliforme while, at the same time, all compounds were inactive against several strains of Gram (+) and Gram (−) bacteria at all assayed concentrations (10?1000 µg/mL).